Clotrimazole is an antifungal agent, widely used in vulvovaginal and oropharyngeal candidiasis.Currently available clotrimazole (especially vaginal) dosage forms, have some limitations, including: leakage, messiness and low residence time, which leads to poor patient compliance.Therefore, in this study, a clotrimazole mucoadhesive gel has been deve
The integrated development of various industries in China is essential for promoting long-term sustainable development and achieving TONER carbon neutrality.In this study, we analyze panel data from 30 Chinese provinces (excluding Tibet, Hong Kong, Macao, and Taiwan) covering the period between 2005 and 2020 to investigate the impact of collaborati
The disaster of the COVID-19 pandemic has claimed numerous lives and wreaked havoc on the entire world due to its transmissible nature.One of the complications of COVID-19 is pneumonia.Different radiography methods, particularly computed tomography (CT), have shown outstanding performance in effectively diagnosing pneumonia.In this paper, we propos
Abstract Background Multiple myeloma (MM) remains an incurable malignancy, despite the advent of therapies such as proteosome inhibitors (PIs) that disrupt protein homeostasis and induce ER stress.We have pursued inhibition of geranylgeranyl diphosphate synthase (GGDPS) as a novel mechanism by which to target protein homeostasis in MM cells.GGDPS i
Photoactive N-hydroxysulfonamides photocaged with the (6-bromo-7-hydroxycoumarin-4-yl)methyl chromophore have been Magnifiers successfully synthesized, and the mechanisms of photodecomposition investigated for two of the compounds.Upon irradiation up to 97% of a diagnostic marker for (H)NO release, sulfinate was observed for the trifluoromethanesul